MICARDIS
Micardis Plus 40mg/12.5mg 1 Tablet
- SKU:
- 004950
- Generic Name:
- Telmisartan Hydrochloroth
Micardis Plus 40mg/12.5mg 1 Tablet
| A. PRODUCT NAME: | Micardis Plus | |
| B. PRODUCT DETAILS: | ||
| Contents/Ingredients | Per 40/12.5 mg tab Telmisartan 40 mg, hydrochlorothiazide 12.5 mg. Per 80/12.5 mg tab Telmisartan 80 mg, hydrochlorothiazide 12.5 mg. Per 80/25 mg tab Telmisartan 80 mg, hydrochlorothiazide 25 mg | |
| Indication/Usage | Essential HTN. Fixed dose combination in patients whose BP is not adequately controlled on telmisartan or hydrochlorothiazide alone. | |
| Dosage and Administration | Adult 1 tab once daily. Patient w/ severe HTN Telmisartan at doses up to 160 mg alone & in combination w/ hydrochlorothiazide 12.5-25 mg daily. Mild to moderate hepatic impairment Should not exceed once daily. Swallow whole w/ liqd. | |
| Warning and Precautions | Symptomatic hypotension in patients who are vol &/or Na depleted by vigorous diuretic therapy, dietary salt restriction, diarrhoea or vomiting. Correct Na or vol depletion before treatment commencement. Hyponatraemia accompanied by neurological symptoms (nausea, progressive disorientation, apathy) w/ hydrochlorothiazide. Impaired hepatic function or progressive liver disease. Renovascular HTN; increased risk of severe hypotension & renal insufficiency in patients w/ bilateral renal artery stenosis or stenosis of artery to single functioning kidney treated w/ medicinal products that affect renin-angiotensin-aldosterone system. Recent kidney transplant. Periodic monitoring of renal function; K, creatinine & uric acid serum levels. Thiazide diuretic-associated azotaemia in patients w/ impaired renal function. Telmisartan is not removed from blood by hemofiltration & is not dialyzable. Dual blockade of renin-angiotensin-aldosterone system. Patients w/ severe CHF or underlying renal disease. Not recommended in patients w/ primary aldosteronism. Patients suffering from aortic or mitral valve stenosis, or obstructive hypertrophic cardiomyopathy. May impair glucose tolerance & manifest latent DM; hyperuricemia may occur, or frank gout may be precipitated during thiazide therapy. Perform periodic determination of serum electrolytes at appropriate intervals. Risk of hypokalaemia in patients w/ cirrhosis of liver, experiencing brisk diuresis, receiving inadequate oral intake of electrolytes & receiving concomitant therapy w/ corticosteroids or ACTH. Concomitant use w/ K-sparing diuretics, K supplements or K-containing salts substitutes. Discontinue before carrying out tests for parathyroid function. Thiazides increase urinary excretion of Mg, resulting in hypomagnesaemia. | |
| Warning and Precautions | Increased risk of fatal MI & unexpected CV death in diabetic patients w/ additional CV risk ie, DM & coexistent CAD. Excessive reduction of BP in patients w/ ischemic cardiopathy or CV disease. History of allergy or bronchial asthma; exacerbation or activation of SLE. Discontinue treatment in the event of photosensitivity reaction occurring during treatment. Protect areas exposed to sun or artificial UVA rays if resumption of treatment is essential. Idiosyncratic reaction resulting in choroidal effusion w/ visual field defect, acute transient myopia & acute angle-closure glaucoma. Risk of non-melanoma skin cancer; regularly check skin for any new lesions & promptly report any suspicious skin lesions. Limit exposure to sunlight & UV rays. Acute resp toxicity, including acute resp distress syndrome. Contains sorbitol; not recommended in patients w/ hereditary fructose intolerance. Contains lactose; not to be taken by patients w/ rare hereditary problems of galactose intolerance, total lactase deficiency or glucose-galactose malabsorption. Avoid potentially hazardous tasks eg, driving or operating machinery if patients experience dizziness, syncope or vertigo. Mild to moderate hepatic impairment. Not recommended in childn & adolescents <18 yr. | |
| Adverse Reactions | Bronchitis, pharyngitis, sinusitis; hypersensitivity; hypokalaemia, hyponatraemia, hyperuricaemia; anxiety, depression, insomnia; dizziness, syncope, paraesthesia, sleep disorders; visual impairment, blurred vision; vertigo; arrhythmias, tachycardia; hypotension, orthostatic hypotension; dyspnoea, resp distress, pneumonitis, pulmonary oedema; diarrhoea, dry mouth, flatulence, abdominal pain, constipation, dyspepsia, vomiting, gastritis, abdominal discomfort; abnormal hepatic function/liver disorder; angioedema (including fatal outcome), erythema, pruritus, rash, hyperhidrosis, urticaria; back pain, muscle spasms, myalgia, arthralgia, pain in extremity, SLE; renal impairment (including acute kidney injury); erectile dysfunction; chest pain, flu-like illness, pain, asthenia; increased blood uric acid & creatinine, hepatic enzyme & blood creatinine phosphokinase. Telmisartan: Sepsis (including fatal outcome), URTI, UTI, cystitis; anaemia, thrombocytopenia, eosinophilia; anaphylactic reaction; hyperkalaemia, hypoglycaemia (in diabetic patients); bradycardia; eczema, drug eruption, toxic skin eruption; tendon pain; decreased Hb. | |
| Adverse Reactions | Hydrochlorothiazide: Basal cell carcinoma, squamous cell carcinoma of skin, lip squamous cell carcinoma; aplastic anaemia, haemolytic anaemia, bone marrow failure, leukopenia, agranulocytosis; decreased appetite, hyperglycaemia, hypomagnesaemia, hypercalcaemia, hypochloraemic alkalosis, hyperlipidaemia, inadequate control of DM; headache; angle-closure glaucoma, choroidal effusion; necrotising vasculitis; acute resp distress syndrome; pancreatitis, nausea; jaundice, cholestasis; TEN, lupus like syndrome, cutaneous lupus erythematosus, photosensitivity reaction, erythema multiforme; glycosuria; pyrexia. | |
| Contraindication | Hypersensitivity to telmisartan, hydrochlorothiazide or other sulphonamide-derived substances. Cholestasis & biliary obstructive disorders. Severe hepatic & renal (CrCl <30 mL/min or serum creatinine >1.8 mg/100 mL) impairment, coma hepaticum, hepatic precoma; anuria, or acute glomerulonephritis. Refractory hypokalaemia, hypercalcaemia. Therapy-refractory hyponatraemia. Hypovolaemia. Symptomatic hyperuricaemia/gout. Concomitant use w/ aliskiren in patients w/ DM or renal impairment (GFR <60 mL/min/1.73 m2). Pregnancy & lactation. | |
| Drug Interaction | Increased risk of lithium toxicity. Increased in serum K w/ K-sparing diuretics, K supplements, salt substitutes containing K or other drugs that may increase serum K levels (eg, heparin Na). Periodic monitoring of serum K w/ drugs affected by serum K disturbances eg, digitalis glycosides, anti-arrhythmic agents & drugs known to induce torsades de pointes. Telmisartan: May increase hypotensive effect of other antihypertensive agents. Increase in median plasma digoxin trough conc. Increased AUC0-24 & Cmax of ramipril & ramiprilat. Reversible increases in serum lithium conc & toxicity. Potential for acute renal insufficiency in patients who are dehydrated w/ NSAIDs (ie, ASA at anti-inflammatory dosage regimens, COX-2 inhibitors & non-selective NSAIDs). Reduced effect by inhibition of vasodilating prostaglandins w/ NSAIDs. Hydrochlorothiazide: Antihypertensive effect can be potentiated by other diuretics, antihypertensive agents, guanethidine, methyldopa, Ca antagonists, ACE inhibitors, ARBs, DRIs, β-receptor blockers, nitrates, barbiturates, phenothiazines, TCAs, vasodilators or alcohol consumption. May reduce diuretic, natriuretic & antihypertensive effects w/ NSAIDs; salicylates & other NSAIDs (eg, indomethacin). Toxic effect of salicylates on CNS may be potentiated in patients taking high-dose salicylates. NSAIDs may trigger acute renal failure in patients developing hypovolaemia during treatment. May possibly increase frequency of hypersensitivity reactions to allopurinol. May possibly increase risk of amantadine-related AR. Increased risk for onset of hyperglycaemia w/ β-receptor blockers. May attenuate effect of insulin or oral antidiabetics, uric acid-lowering agents, norepinephrine & epinephrine. | |
| Increased myocardial sensitivity to cardiac glycosides by any hypokalaemia &/or hypomagnesaemia that develops during therapy, thereby potentiating effects & adverse effects of cardiac glycosides. Increased K loss w/ kaliuretic diuretics (eg, furosemide), glucocorticoids, ACTH, carbenoxolone, penicillin G, salicylates, amphotericin B, antiarrhythmics or laxatives. Increased risk of acute functional renal failure in the event of dehydration caused by diuretics particularly during use of high doses of iodinated contrast products. Increased Na loss w/ natriuretic diuretics & antidepressants, antipsychotics or antiepileptics. Reduction in renal excretion of cytotoxic agents (eg, cyclophosphamide, fluorouracil, MTX) & increased bone marrow toxicity (especially granulocytopenia). Bioavailability may be increased by anticholinergic agents (eg, atropine, biperiden) due to decrease in GI motility & gastric emptying rate. May reduce bioavailability w/ prokinetic medicinal products eg, cisapride. Reduced renal clearance of lithium; increase plasma lithium levels; potentiation of cardio- & neurotoxic effects of lithium due to decreased lithium excretion. Potentiated or prolonged effect of curare-like muscle relaxants. Reduced absorption w/ cholestyramine or colestipol. May reduce excretion of Ca via urine & potentiate increase of Ca in serum w/ vit D. Hypercalcaemia may occur due to increase in tubular Ca reuptake w/ Ca salts. May increase risk of hyperuricaemia & gout-like complications w/ ciclosporin. Increased hyperglycaemic effect of diazoxide. Haemolysis caused by formation of Ab w/ methyldopa. May reduce response to adrenergic amines eg, norepinephrine. | ||
| Requires Prescription? (Yes or No) | Yes | |
| Storage Conditions | Store at temperatures not exceeding 30ºC | |
| C. PRODUCT INFORMATION | ||
| Generic Name | Telmisartan + Hydroclorothiazide | |
| Strength | 40 mg/12.5 mg | |
| Dosage Form | Tablet | |
| Manufacturer | Boehringer Ingelheim Ellas A. E. | |
| Place of Origin | Greece | |
| Brand | Micardis Plus | |
| Regulatory Classification | Rx | |
1. We will deliver orders in the following areas (except in island barangays).
| a) Pangasinan ✔ Dagupan City |
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| b) La Union ✔ Agoo |
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| c) Ilocos Sur ✔ Tagudin |
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| d) Ilocos Norte ✔ Laoag City |
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| e) Bataan ✔ Orion |
|
| f) Abra ✔ Bangued |
|
| g) Pampanga ✔ Angeles City |
2. There are two (2) ways to receive your order:
a) via Home Delivery
b) via Store Pickup in any of the following St. Joseph Drug (pick-up point)i> branches:
✔ Perez Blvd., Dagupan City
✔ Mabini St., Poblacion West, Calasiao, Pangasinan
✔ Rizal St. corner Biagtan St., Poblacion, Mangaldan, Pangasinan
✔ Rizal St., Poblacion, San Fabian, Pangasinan
✔ Charms Bldg., Poblacion, Pozzorubio, Pangasinan
✔ CB Mall, Mc Arthur Highway, Nancayasan, Urdaneta, Pangasinan
✔ Zone 1 Market Road corner McArthur Highway, Villasis, Pangasinan
✔ Roxas corner Malong St., San Carlos, Pangasinan
✔ Calvo St., Mangatarem, Pangasinan
✔ Poblacion, Basista, Pangasinan
✔ Poblacion, Binmaley, Pangasinan
✔ Solis St., Brgy. Poblacion, Lingayen, Pangasinan
✔ Poblacion, Quezon Avenue, Alaminos, Pangasinan
✔ Concordia (Pob.), Bolinao, Pangasinan
✔ National Road, Poblacion, Bani, Pangasinan
✔ Mother Goose Bldg., Tapuac District, Dagupan City, Pangasinan
✔ Joleco Bldg., I, A.B. Fernandez Ave., Dagupan City, Pangasinan
✔ E&J Bldg., Milo Street, Manaoag, Pangasinan
✔ Panda Ave., Poblacion, Mapandan, Pangasinan
✔ San Guillermo, San Jacinto, Pangasinan
✔ Blue Horizon Bldg., Quezon Blvd., Poblacion, Alaminos City, Pangasinan
✔ CentroMart, Rizal St., Lingayen, Pangasinan
✔ Poblacion, Aguilar, Pangasinan
✔ Romulo Highway, Poblacion, Bugallon ,Pangasinan
✔ Gen. Luna St., Poblacion, Rosales, Pangasinan
✔ Quezon Blvd., Tayug, Pangasinan
✔ National Road, Umingan, Pangasinan
✔ Poblacion East, Alcala, Pangasinan
✔ M.H. Del Pilar St., Bayambang, Pangasinan
✔ CSI, Malasiqui, Pangasinan
✔ P. Tavera St., Poblacion, Binalonan, Pangasinan
✔ Guiset Sur, San Manuel, Pangasinan
✔ Poblacion West, Asingan, Pangasinan
✔ G/F Magic Mall, Alexander St., Urdaneta City, Pangasinan
✔ Poblacion, Infanta, Pangasinan
✔ Agbayani St., Poblacion, Sual, Pangasinan
✔ Poblacion, Urbiztondo, Pangasinan
✔ Poblacion, Sta.Barbara, Pangasinan
✔ Victoria Rd., San Nicolas Norte, Agoo, La Union
✔ CSI City Mall, Biday, San Fernando City, La Union
✔ Osmeña Street, San Fernando City, La Union
✔ Poblacion East, Rosario, La Union
✔ Brgy. Lacong, Tagudin, Ilocos Sur
✔ Hennady Bldg. McArthur Poblacion, Brgy. V, Bantay, Ilocos Sur
✔ National Highway, San Antonio, Candon City, Ilocos Sur
✔ Quezon Avenue, Vigan City, Ilocos Sur
✔ City Galore Square, J.P. Rizal cor. Ligo St., Laoag City, Ilocos Norte
✔ Trece Grande Bldg., 187 JP Rizal St. Cor. Dr. Damaso Samonte St. Brgy 19, Laoag City, Ilocos Norte
✔ National Road, San Vicente, Orion, Bataan
✔ Taft St., Zone 5, Bangued, Abra
✔ Washington St., Brgy 2 Abian, Batac, Ilocos Norte
✔ Middle Session, Baguio City, Benguet
✔ G/F Senvik Loy Bldg., La Trinindad, Benguet
✔ CSI Warehouse, Purok I Palanginan, Iba, Zambales
✔ Magic Mall, Poblacion, Sta. Cruz, Zambales
✔ Sto. Rosario St., Sto. Domingo, Angeles City, Pampanga
3. We charge the following delivery fee:
| Mode of Delivery | Delivery Fee |
|---|---|
| Home Delivery | Delivery fee starts at P60.00 for the first four (4) kilometers. Additional amount will be charged depending on the distance of the shipping address you specified (please refer to the Shipping Fee Directory). |
| Store Pickup | Free of Charge |
4. We will deliver your order as follows:
a) for Home Delivery
| Orders Received | Delivery Schedule |
|---|---|
| Before 1:00pm | Same day delivery within 2:00pm to 6:00pm |
| After 1:00pm | Next day delivery within 2:00pm to 6:00pm |
b) for Store Pick-up
You may expect your order to be ready within 2 hours to a day (depending on the availability of ordered item) upon placement of order. You will be notified via call/SMS once your order is ready for pick-up. We encourage you to claim your order within 3 days (during store hours) upon receipt of advice that your order is ready for pick-up, otherwise, such shall deemed as cancelled.
5. We will deliver your order from Monday to Sunday (including holidays) from 2:00pm to 6:00pm.
6. There are two (2) ways to track your order:
a) For every change in the order status, an email will be sent to you.
b) You can also check your order status by signing-in to your account. Just go to “My Account” and click “Orders” to display the order status.
7. In case you are not home when your order arrives, you may have a representative receive and pay the package for you. However, if payment was made via bank transfer, your representative shall be required to present the following:
a) Authorization Letter; and
b) Your Valid ID (with picture and signature) and that of your representative.
8. If nobody is available to receive your order, our Rider will bring your package back to St. Joseph Drug pick-up point branch nearest/ covering the shipping address you specified, for pick-up within the 3-day claiming period or you can have it redelivered but with a corresponding redelivery fee.
ITEM RETURN/ EXCHANGE/ REFUND1. All products ordered from St. Joseph Drug are subject to quality checking by our designated personnel prior to delivery to/ pick-up by customers.
a) Upon delivery to / pick-up by customer:
✔ Please inspect your package in the presence of our Rider/Pharmacy Assistant. Your signature on the Acknowledgement Receipt signifies that you have received the products completely, correctly, and in good condition (not damaged / defective and / or expiring / expired).
✔ You may refuse to accept the product if such is incorrect, incomplete, or not in good condition. For home delivery, we will redeliver the replacement or additional item/quantity free of delivery charge.
b) After delivery to / pick-up by customer:
✔ We will still accommodate request for item return / exchange / refund under the following conditions:
- Promptly returned within 7 days upon receipt of the product
- Duly supported by St. Joseph Drug official receipt
Note : We may require additional documents (e.g. photo of the affected product) to support your request.
✔ The following items will be acceptable:
- items in good condition provided such are:
- not in a vial
- not loose tablets/capsules
Note : The product must be in its original box/packaging (unused) and complete with gift/promo item (if any).
- products with explicit manufacturing defect
Note : Damaged / defective items due to customer's mishandling or improper use will not be accepted.
✔ Once your request is approved, we will redeliver the replacement or additional item/quantity but with a corresponding redelivery fee (except for products with explicit manufacturing defect which we will redeliver free of delivery charge).
✔ Requests for refund will be reviewed and handled on a case-by-case basis and subject to management's approval.
2. To request for item return/ exchange/ refund, perform any of the following:
a) contact 0917-565-3700 or 0998-530-3700; or
b) report via our live chat/ messaging; or
c) proceed to St. Joseph Drug Perez Blvd., Dagupan City branch.
Note : Request for return/ exchange/ refund of items ordered via our Online Store will not be accepted in any other St. Joseph Drug branches.
3. Requests for item return/ exchange/ refund will be processed within 2-3 working days upon receipt of the required supporting documents. You shall be notified via call/ SMS once the request has been approved.
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