Mestinon 60mg 1 Tablet
₱47.50
| Generic Name | Pyridostigmine Bromide |
| Strength | Amber Bottle x 150's Box of 1's |
| Indication/Usage | treatment of myasthenia gravis. |
| Dosage and Administration | When using Mestinon"', it is important to remember that the full effect appears gradually, usually within 15-30 minutes. Use in Adult 1-3 Dragees (60-180mg) 2-4 times daily, or higher doses it required. T~e total daily dose is usually in the range of 5.-20 Dragees (300mg - 1200mg) but doses hlqher than these may be needed by some patients Use in Children Children under 6 years old should receive an initial dose of 30mg of Mestlncn". Children 6 - 12 years old should receive 60mg. Dosage should increase gradually, .in Increments of 15 - 30mg dally, until maximum Improvement IS obtained. Total dally requirements are usually in the range to 30 - 360mg. Patients with swallowing difficulties can take tablets broken into small pieces instead of the whole tahlets or Dragees. In Myasthenia gralJls, one dose is effective for approximately four hours during the day \'vtlilst at night (owlflgto reduced physical activity), a longer duration of effect of around 6 hours can be expected. It is recommended that tile times of administration be chosen so that the maximum effect ccncdes with the most strenuous physical exertion, e.g.lNhen getting up and at mealtimes. Speast dosage instructiOI1S The required dose must be carefully titrated when used in paediatrics. In cases of neonatal myasthenia, generally one treatment with neostigmine (Prostigmine) IS preferred. However, it this appears unsuitable due to excessively cholinergic side effects, then Mestinoo'" can be administered. In these cases, the following serves as a rough guideline 5-10mg by mouth in tablet form, 30-60 minutes before food. Treatment over the eighth week of lite is required only in extremely rare cases of congenital and familial illfantile myasmerua. |
| Warning and Precautions | Mestinon' is contraindicated in mechanical obstruction of the intestinal or urinary tract and known allergy to the preparation. Pvndostiqmme is mainly excreted unchanqed by the kidney. Therefore, lower doses may be reqUired In patients With renal disease, and treatment should be based on titration. of drug dosage to effect. Although failure of patients to show. clin cal improve.ment may reflect under dosage, i.t can atso be incicative of ov~rdos~ge. As IS true 01 allcholinerqc dru.gs, overdosage of Mesllfl?"~ may result In cholinerqlc cnSIS, a state charactensed by mcreasmq muscle weaknes~ I'JhIC~, through in~olveme~t of the muscles 01 respiration. may lead to death. MyastheniC crisis due to an mcrease m the seventy of the disease is also accompanied by extreme muscle weakness, and thus may be difficult to distinguish from cholinergic crisis on a symptomatic basis. Such differentiation is extremely important, since increases in doses of Mestlnon~ or other drugs of this class lnthe presence 01 cholinergic crisis 0 r ot n re'ractcrv or "insensitive" state could have a qrave consequence. The different diagnosis ?f.the two types of crisis may require the use of Tensilon (edrophonium chloride) as well as clinical Judgment. The treatment of the two conditions obviously differs radically. WIlereas the presence of myasthenic crisis suggestslhe need 101 more intensive anti-cholinesterase therapy, the diagno~is of cholinergi~ crisis, cal.ls for. the prompt withdrawal of all drugs of this type. The immediate use of atropine In cholinergic crisis is also recommended . Atropine may abolish Of obtund gastrointestinal side effects or other muscarinic reactions; but such use, by masking the signs of overdosage, can lead to inadvertent induction of chclinergc crists. |
| Adverse Reactions | like all cholinergic drugs, Mestinon~ can have undearade nnc'ional effects on the autooomic nervous system. Muscarine-type side effects can manifest themselves as nausea, vomiting, diarrhoea, stomach cramps, increased peristalsis and bronchial secretion, salivation and lacrimation as well as bradycardia and miosis. Nicotine-type side effects consist mainly of muscle spasms; muscle twitches and muscle weakness. like other bromine-containing drugs, Meslinon: can occasionally cause skin rash, althoeqh this generally disappears. rapidly o~ce medication has heen discontinued. Further use of Mestinon~ or other bromine-containing preparations is then contra-Indicated. |
| Contraindication | Mestinon' is contraindicated in mechanical obstruction of the intestinal or urinary tract and known allergy to the preparation. Pvndostiqmme is mainly excreted unchanqed by the kidney. Therefore, lower doses may be reqUired In patients With renal disease, and treatment should be based on titration. of drug dosage to effect. |
| Drug Interaction | Pyridostigmine antagonises the action of curare-like non-dcpolansinq muscle relaxants. Atropine counteracts the cholinergic effects of pyridostigmine. |
| Requires Prescription? (Yes or No) | Yes |
| Overdose and Treatment | Overdosage with Mestlnon" or other cholinesterase inhibitors can lead to cholinergic crises that mantest themsetves in, among other things, pronounced muscle weakness (or exacerbated muscle weakness in patients with myasthenia). If such a situation is overlooked, llte is endangered due to paralysis of the respiratory muscles. Bradycardia and - pal a.doxically, tachycardia are other posslele ettects. Countermeasures include the Immediate Withdrawal of Mestlnoo.!- or other cholinerglcs and the slow Intravenous administration of 1-2mg atropine sulphate. Depending on the pulse rate, this dose is to be repeated at intervals 01 two to four hours If required. |
| Storage Conditions | Store at temperatures not exceeding 30ºC |
Related Products
Angiozem 60mg 1 Tablet
₱30.00
IMPORTANT NOTICE:For this product, a doctor's prescription is required. Please do not forget to attach a copy of your valid prescription(.jpeg, bmp, gif, jpg, jpeg, jpe, jif, jfif, jfi, png, wbmp,...
